Study: nitrate improves mitochondrial efficiency

by Editor fleischwirtschaft.com
Monday, February 07, 2011

C. Dietary nitrate has profound positive effects on mitochondrial function, as well as whole-body oxygen consumption during exercise, according to a new study by the Swedish School of Sport and Health Sciences.

In a double-blind crossover trial, researchers studied the effects of a dietary intervention with inorganic nitrate on basal mitochondrial function and whole-body oxygen consumption in healthy volunteers.

Nitrite supplementation was found to help the human body produce energy or ATP (Adenosine triphosphate) during oxidative phosporylation with less oxygen. ATP is an energy molecule found, made and used in the body. This was seen in muscle mitochondria harvested after nitrate supplementation displayed an improvement in oxidative phosphorylation efficiency (P/O ratio) and a decrease in respiration.

The improved mitochondrial P/O ratio correlated to the reduction in oxygen cost during exercise. Nitrate also reduced the expression of ATP/ADP translocase, a protein involved in the body’s ability to conduct internal electric charges. These charges are essential in nerve functionality and muscle movement.

The study can be viewed here.
stats